Drug Innovation Platform
Integrated application of biosynthetic technology to promote the innovation of macromolecules and micromolecules
Drug Innovation Platform
Integrated application of biosynthetic technology to promote the innovation of macromolecules and micromolecules
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Natural products have always been an important source of drug discovery. Our advantages in protein evolution, biosynthetic pathway design, and chassis construction allow our platform to utilize the integrated strategy of synthetic biology and "made-to-order" biosynthetic pathway. As a result, we can precisely modify the structure of complex natural products and construct different types of bioactive compound libraries for pharmaceutical research.
Traditional medicine innovation based on chemical synthesis cannot easily achieve precise structural modification of complex natural products. Our drug innovation platform supported by synthetic biology not only makes up for the technical shortcomings of traditional drug innovation, but also avoids other drawbacks such as long synthetic paths, environmental pollution, and difficulty in chirality. This approach falls in line with the current sustainable development concept of "green health" and "carbon neutrality".
Our drug innovation platform fully integrates our advantages in enzyme evolution, synthetic pathway design, and chassis cell construction. Through the integration of quality multi-dimensional (transcriptome, proteome, and metabolome) analysis and testing methods, we can provide an efficiently integrated experimental program for natural drug structural modification and pharmaceutical activity research.
Our drug innovation platform also focuses on the innovation of biological macromolecules and active peptides. It develops peptides, antibodies, and antibody-conjugated drugs (ADCs) through phage display, enzymatic macromolecular labeling, and homogenous antibody conjugation technologies. Comprehensive strategies aid in obtaining natural medicines with high biological activity and novel chemical structures.